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Clitoris-sparing surgery, which was only probable as a consequence of the utilization of
Edelweiss M, Malpica A: Dermatofibrosarcoma protuberans with the vulva: a clinicopathologic and immunohistochemical study of 13 instances. Am J Surg Pathol 2010, 34:393?00. two. Molina AS: Dermatofibrossarcoma protuberans: An ise dos marcadores de prolifera o celular, invasividade e apoptose. Estudo da fus de3.4.5.six. 7.eight.9.10. 11. 12. 13. 14. 15.16. 17. 18. 19.20. 21.22. 23.24.25.26.col-11/pdgf- por fish e correla o com a recidiva. MSc thesis. Funda o Antonio Prudente, Oncology; 2011 [http://accamargo.phlnet.com. br/MESTRADO/2012/AndreMolina/AndreMolina] Doufekas K, Duncan TJ, Williamson KM, Varma S, Nunns D: Mohs micrographic surgery for dermatofibrosarcoma protuberans with the vulva. Obstet Gynecol Int 2009, 2009:1?. Farma JM, Ammori JB, Zager JS, Marzban SS, Bui MM, Bichakjian CK, Johnson TM, Lowe L, Sabel MS, Wong SL, Douglas Letson G, Messina JL, Cimmino VM, Sondak VK: Dermatofibrosarcoma protuberans: how wide really should we resect? Ann Surg Oncol 2010, 17:2112?118. H ner HM, Moehrle M, Eder S, Trilling B, R ken M, Breuninger H: 3D Histological evaluation of surgery in dermatofibrosarcoma protuberans and malignant fibrous histiocytoma: Differences in growth patterns and outcome.Clitoris-sparing surgery, which was only feasible due to the utilization of the CCPDMA protocol by our Pathology Division. We conclude that vulvar DFSP, though an incredibly difficult lesion that normally implies tough surgical management, if treated within a multidisciplinary environment with surgical oncologists, experienced pathologists and reconstructive surgeons, can reach great outcomes. And even in difficult situations that present with significant lesions and compromising challenging places, a comprehensive oncologicresection could be performed, minimizing PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25679764 functional harm for the patient.Abbreviations DFSP: dermatofibrosarcoma protuberans; WLE: wide nearby excision; CCPDMA: 3-dimensional comprehensive circumferential and peripheral deep margin assessment; IHC: immunohistochemistry; COL1A1: collagen type I alpha 1; PGDF: Platelet-derived growth factor B-chain. Competing interests The authors declare that they have no competing interests. Authors‘ contributions The Skin Cancer Division staff (EB, ERB, WRC, MC, ASM, JPDN) was involved in the diagnosis, management and post-operative recovery with the individuals. The Gynecology Oncology Division employees (GB) was also involved with all the operative proceedings in each cases. The Pathology department (MPM, IWC, CALP) was accountable for the CCPDMA and pathological reports in each situations. All authors have contributed using the literature critique and using the preparation of this manuscript. All authors study and PlumbaginCancer approved the final manuscript. Acknowledgement We acknowledge A.C. Camargo Cancer Center for institutional assistance. Author facts 1 Skin Cancer Department, AC Camargo Cancer Center, Rua Professor Antonio Prudente 211, 01509-900 S Paulo, Brazil. 2Gynecologic Oncology Division, AC Camargo Cancer Center, Rua Professor Antonio Prudente 211, 01509-900 S Paulo, Brazil. 3Pathology Department, AC Camargo Cancer Center, Rua Professor Antonio Prudente 211, 01509-900 S Paulo, Brazil. Received: 18 August 2014 Accepted: 3 December 2014 Published: 29 December 2014 References 1. Edelweiss M, Malpica A: Dermatofibrosarcoma protuberans in the vulva: a clinicopathologic and immunohistochemical study of 13 instances. Am J Surg Pathol 2010, 34:393?00. 2. Molina AS: Dermatofibrossarcoma protuberans: An ise dos marcadores de prolifera o celular, invasividade e apoptose. Estudo da fus de3.4.5.6. 7.eight.9.10. 11. 12.
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