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发布于:2018-12-21 19:00:18  访问:80 次 回复:0 篇
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Haplotypes of B6 and BALB/c mice. In addition, the MHC class
For these motives, and since the collected AXBXA set is substantially AMG-176 custom synthesis larger (26 strains) than the previously studied families, we investigated the outcome of immunizing AXBXA strains with adenovirus expressing the TSHR A-subunit. However, two of 20 B6XAF1 mice immunized with TSHR A-subunit-Ad had been clearly hyperthyroid (Fig. 1B).Response of recombinant AXBXA strains to A-subunit adenovirus immunizationAfter immunization with A-subunit-Ad, 15 of 26 AXBXA strains created low TBI levels, from just about negative to ,50 inhibition of TSH binding (Fig. 2A; strains ranked left to ideal for TBI, lowest to highest). The TBI response within the other 11 strains was extra robust (.50 ). TBI values were similar after two or three immunizations (Fig. 2A, speckled versus strong bars, respectively). In contrast, when measured by ELISA, TSHR antibody levels for some strains have been reduce after the third versus the second immunization (Fig. 2B). Furthermore, the rank order for TSHR antibodies measured by ELISA differed from that for TBI.Haplotypes of B6 and BALB/c mice. In addition, the MHC class I genes of A strain mice are a mixture of k- and dhaplotypes [20]. For these reasons, and because the collected AXBXA set is substantially bigger (26 strains) than the previously studied households, we investigated the outcome of immunizing AXBXA strains with adenovirus expressing the TSHR A-subunit. Our findings offer several unexpected and intriguing results, particularly in relation to the contribution of MHC area genes to the generation of TSHR antibodies.Results TSHR antibodies and hyperthyroidism induced inside a and B6 mice and their F1 offspringMice of the A/J strain (referred to as ``A‘‘) immunized three times with TSHR A-subunit-Ad developed significantly reduced TSHR antibody levels (measured by TSH binding inhibition, TBI) than either B6 mice or the F1 hybrids (B6XAF1) between the two parental strains (Fig. 1A; p ,0.05, ANOVA). When it comes to thyroid function, no A strain mice and PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/19370553 only a single B6 mouse had elevated serum T4 compared with Con-Ad immunized animals from the same strain. Nonetheless, two of 20 B6XAF1 mice immunized with TSHR A-subunit-Ad were clearly hyperthyroid (Fig. 1B).Response of recombinant AXBXA strains to A-subunit adenovirus immunizationAfter immunization with A-subunit-Ad, 15 of 26 AXBXA strains developed low TBI levels, from virtually damaging to ,50 inhibition of TSH binding (Fig. 2A; strains ranked left to correct for TBI, lowest to highest). The TBI response in the other 11 strains was extra robust (.50 ). TBI values have been comparable soon after two or 3 immunizations (Fig. 2A, speckled versus solid bars, respectively). In contrast, when measured by ELISA, TSHR antibody levels for some strains have been reduce just after the third versus the second immunization (Fig. 2B). Moreover, the rank order for TSHR antibodies measured by ELISA differed from that for TBI. Focusing on the strains with strong TBI responses, TSHR antibodies measured PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/24204793 by ELISA were disproportionately low, indeed virtually undetectable, in strains BXA2, BXA13 and BXA1 (labeled B2, B13 and B1) (Fig. 2B versus 2A). Turning to thyroid function, T4 levels had been practically unchanged in AXBXA strains right after two immunizations (information not shown).
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