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发布于:2018-12-14 12:41:33  访问:43 次 回复:0 篇
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The German Trauma Registry database including 17,200 multiple injured patients to determine
The German Trauma Registry Firategrast Cytoskeleton database including 17,200 multiple injured patients to determine to what extent clinically relevant coagulopathy has already been established upon ER admission, and whether its presence was associated with impaired outcome and Schisandrin B 61281-37-6 pubmed ID:https://www.ncbi.nlm.nih.gov/pubmed/28494239 mortality. Results The study showed that APC levels were significantly lower in patients PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27488460 with SIRS compared with control subjects (38.6 ?23 vs 87.8 ?6.1 P < 0.0001) respectively. When we compared levels in survivors and nonsurvivors, the former showed a persistent rise of the level to normal values in contrast to the latter,SAvailable online http://ccforum.com/supplements/10/SP159 Antithrombin reduces ischemia/reperfusion-induced liver injury in mice by enhancing the activation of sensory neurons through protein kinase A activationN Harada1, K Okajima1, H Kuhihara2, N Nakagata3 of Biodefense Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; 2Department of Physiological Chemistry and Metabolism, University of Tokyo Graduate School of Medicine, Tokyo, Japan; 3Division of Reproductive Engineering, Center for Animal Resources and Development, Kumamoto University, Kumamoto, Japan Critical Care 2006, 10(Suppl 1):P159 (doi:10.1186/cc4506)1DepartmentWe recently demonstrated that antithrombin (AT) reduces ischemia/reperfusion (I/R)-induce.The German Trauma Registry database including 17,200 multiple injured patients to determine to what extent clinically relevant coagulopathy has already been established upon ER admission, and whether its presence was associated with impaired outcome and PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28494239 mortality. Results A total of 8724 patients with complete data sets were screened. Coagulopathy upon ER admission was present in 2989 (34.2 ) of all patients. Males were more affected than females (72.5 vs 27.5 ) and in 96 the trauma mechanism was blunt. The mean ISS score in the coagulopathy group was 30 ?15, while trauma patients without coagulopathy upon ER admission generally presented with lower ISS scores (mean ISS 21 ?12; P < 0.001). Twenty-nine percent of patients with coagulopathy developed multiorgan failure (P < 0.001). Early inhospital mortality (<24 hours) was 13 in patients with coagulopathy (P < 0.001) and overall inhospital mortality totalled 28 (P < 0.001). Conclusion There is a high frequency of established coagulopathy in multiply injury upon ER admission. The presence of early traumatic coagulopathy was associated with injury severity and impaired outcome. Acknowledgements Supported by the AG Polytrauma of the German Trauma Society (DGU) and the Merheim Coagulation Study Group (MCSG).P157 Altered coagulation in systemic inflammatory response syndrome: role of protein C in diagnosis and prognosisA Rizk, A El Naggar, M Affify, S Mokhtar Cairo University, Cairo, Egypt Critical Care 2006, 10(Suppl 1):P157 (doi:10.1186/cc4504) Background Evidence has accumulated to suggest that more complex mechanisms might be involved in the relationship between inflammation and coagulation. Objective In this study we aimed to use some coagulation markers, especially activated protein C (APC), in the diagnosis and prognosis of patients with systemic inflammatory response syndrome (SIRs), whether infectious or non-infectious. Methods We enrolled 20 patients who had been hospitalized for SIRs as well as 20 age-matched and sex-matched subjects who served as the control group.
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